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Microbiome2023-02-11T03:57:30+00:00

The Role of the Microbiome in Autism

Increasing evidence suggests that the enteric microbiome plays a critical role in the etiology and symptomatology of ASD, at least in some cases. To better understand this connection, the International Symposium on the Microbiome in Health and Disease has been organized to focus on novel approaches for studying and manipulating the enteric microbiome to improve autism symptoms. From this meeting a special issue of Microbial Ecology in Health and Disease was published. We have also investigated the clinical and basic research aspects of enteric microbiome metabolites on mitochondrial function.

This page contains a selection of papers and other resources on this topic. You can also search this site and all types of content by creating a custom filter.

Autism Parents

Published Articles

Results are displayed in descending order beginning with most recent publications.

Feeding-Related Early Signs of Autism Spectrum Disorder: A Narrative Review

Categories: Published Articles|Tags: , , , |

Castro K, Frye RE, Silva E, Vasconcelos C, Hoffmann L, Riesgo R, Vaz J. 3  2024. Journal of Personalized Medicine.; 14(8):823.

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Synchrony 2022: Catalyzing Research and Treatments to Benefit Individuals with Neurodevelopmental Disorders including Autism Spectrum Disorders

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Nanda, H.; Frye, R.E. Synchrony 2022: Catalyzing Research and Treatments to Benefit Individuals with Neurodevelopmental Disorders including Autism Spectrum Disorders. J. Pers. Med. 2023, 13, 490. https://doi.org/10.3390/jpm13030490

Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism

Categories: Published Articles|Tags: , , , , , , , |

Rose S, Bennuri SC, Davis JE, Wynne R, Slattery JC, Tippett M, Delhey L, Melnyk S, Kahler SG, MacFabe DF, Frye RE. Transl Psychiatry. 2018 Feb 2;8(1):42. doi: 10.1038/s41398-017-0089-z. PMID: 29391397; PMCID: PMC5804031.

Modulation of Immunological Pathways in Autistic and Neurotypical Lymphoblastoid Cell Lines by the Enteric Microbiome Metabolite Propionic Acid

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Frye RE, Rose S, Chacko J, Wynne R, Bennuri SC, Slattery JC, Tippett M, Delhey L, Melnyk S, Kahler SG, MacFabe DF. Transl Psychiatry. 2016 Oct 25;6(10):e927. doi: 10.1038/tp.2016.189. PMID: 27779624; PMCID: PMC5290345.

Modulation of mitochondrial function by the microbiome metabolite propionic acid in autism and control cell lines

Categories: Published Articles|Tags: , , , , , , , , |

Frye RE, Rose S, Chacko J, Wynne R, Bennuri SC, Slattery JC, Tippett M, Delhey L, Melnyk S, Kahler SG, MacFabe DF. Transl Psychiatry. 2016 Oct 25;6(10):e927. doi: 10.1038/tp.2016.189. PMID: 27779624; PMCID: PMC5290345.

The Significance of the Enteric Microbiome on the Development of Childhood Disease: A Review of Prebiotic and Probiotic Therapies in Disorders of Childhood.

Categories: Published Articles|Tags: , , , |

Rose, S., Bennuri, S..C, Davis, J.E., Wynne, R., Slattery, J.C., Tippett, M., Delhey, L., Melnyk, S., Kahler, S.G., MacFabe, D.F., Frye, R.E.. Transl Psychiatry. 2018; 8(1):42.

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Approaches to studying and manipulating the enteric microbiome to improve autism symptoms

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Frye RE, Slattery J, MacFabe DF, Allen-Vercoe E, Parker W, Rodakis J, Adams JB, Krajmalnik-Brown R, Bolte E, Kahler S, Jennings J, James J, Cerniglia CE, Midtvedt T. Microb Ecol Health Dis. 2015 May 7;26:26878. doi: 10.3402/mehd.v26.26878. PMID: 25956237; PMCID: PMC4425814.

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