mRNA

You are here:Home/mRNA
mRNA2023-02-20T03:05:44+00:00

mRNA in Autism Spectrum Disorder

Mutations in hundreds of different genes contribute to to the risk of Autism spectrum disorder (ASD). Studies have shown that significant differences in the ASD-associated miRNA expression profiles are found in a variety of target tissues (e.g., saliva, blood, serum and brain). In some studies, significant dysregulation of specific miRNAs has been found in lymphoblastoid cell lines (LCLs) of ASD patients compared to their typically-developing siblings and controls. Overall, these findings suggest that mRNA and miRNA expression profiles in ASD reveal numerous miRNA–gene interactions that regulate critical pathways involved in the proliferation of neuronal cells, cell death of immune cells, and neuronal development. This is a promising area for future discoveries and possible treatments.

This page contains a selection of papers and other resources on this topic. You can also search this site and all types of content by creating a custom filter.

Autism Parents

Published Articles

Results are displayed in descending order beginning with most recent publications.

Blood RNA Sequencing Indicates Upregulated BATF2 and LY6E and Downregulated ISG15 and MT2A Expression in Children with Autism Spectrum Disorder

Categories: Published Articles|Tags: , , , |

Voinsky, I.; Zoabi, Y.; Shomron, N.; Harel, M.; Cassuto, H.; Tam, J.; Rose, S.; Scheck, A.C.; Karim, M.A.; Frye, R.E.; Aran, A.; Gurwitz, D. Blood RNA Sequencing Indicates Upregulated BATF2 and LY6E and Downregulated ISG15 and MT2A Expression in Children with Autism Spectrum Disorder. Int. J. Mol. Sci. 2022, 23, 9843. https://doi.org/10.3390/ijms23179843

Integrated microRNA–mRNA Expression Profiling Identifies Novel Targets and Networks Associated with Autism

Categories: Published Articles|Tags: , , , |

Gill, P.S.; Dweep, H.; Rose, S.; Wickramasinghe, P.J.; Vyas, K.K.; McCullough, S.; Porter-Gill, P.A.; Frye, R.E. Integrated microRNA–mRNA Expression Profiling Identifies Novel Targets and Networks Associated with Autism. J. Pers. Med. 2022, 12, 920. https://doi.org/10.3390/jpm12060920

MicroRNA Expression Profiles in Autism Spectrum Disorder: Role for miR-181 in Immunomodulation

Categories: Published Articles|Tags: , , , |

Frye RE, Rose S, McCullough S, Bennuri SC, Porter-Gill PA, Dweep H, Gill PS. MicroRNA Expression Profiles in Autism Spectrum Disorder: Role for miR-181 in Immunomodulation. J Pers Med. 2021 Sep 17;11(9):922. doi: 10.3390/jpm11090922. PMID: 34575699; PMCID: PMC8469245.

Peripheral Blood Mononuclear Cell Oxytocin and Vasopressin Receptor Expression Positively Correlates with Social and Behavioral Function in Children with Autism

Categories: Published Articles|Tags: , , , |

Voinsky, I., Bennuri, S.C., Svigals, J. et al. Peripheral Blood Mononuclear Cell Oxytocin and Vasopressin Receptor Expression Positively Correlates with Social and Behavioral Function in Children with Autism. Sci Rep 9, 13443 (2019). https://doi.org/10.1038/s41598-019-49617-9

Serum microRNAs in ASD: Association With Monocyte Cytokine Profiles and Mitochondrial Respiration

Categories: Published Articles|Tags: , , , |

Jyonouchi H, Geng L, Toruner GA, Rose S, Bennuri SC, Frye RE. Serum microRNAs in ASD: Association With Monocyte Cytokine Profiles and Mitochondrial Respiration. Front Psychiatry. 2019 Sep 10;10:614. doi: 10.3389/fpsyt.2019.00614. PMID: 31551826; PMCID: PMC6748029.

Title

Go to Top