Cerebral Folate Deficiency (CFD)
Folate receptor α (FRα) autoantibodies (FRAAs) are prevalent in autism spectrum disorder (ASD). They disrupt the transportation of folate across the blood-brain barrier by binding to the FRα. Children with ASD and FRAAs have been reported to respond well to treatment with a form of folate known as folinic acid, suggesting that they may be an important ASD subgroup to identify and treat.
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Published Articles
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Other Resources
CEREBRAL FOLATE DEFICIENCY IN ASD
from The Journal of Autismone
CENTRAL FOLATE ABNORMALITIES
from Autism File
Folate Receptor Alpha Autoantibody Test (FRAT)
Folate Receptor Alpha Autoantibody Test (FRAT)
This test measures two proteins in the blood called autoantibodies whichinterfere with the ability of the vitamin folate to be used by the brain and other parts of the body.The two autoantibodies are called ‘blocking’ and ‘blinding’ and then each may be ‘negative’, ‘low’, ‘medium’ or ‘high.’