Neuroimaging in Autism Spectrum Disorder
Neuroimaging has uncovered connectivity abnormalities in the brains of individuals with autism spectrum disorders (ASD). The precise connectivity abnormalities and the relationship between these abnormalities and cognition/ASD symptoms is unknown. Functional magnetic resonance imaging and other advances in neuroimaging may have clinical utility as non-invasive ways to investigate these neurochemical alterations in ASD. MRI provides dynamic insight into the functional organization of the brains’ activity and measures the function of neurotransmitter-driven networks. New applications of neuroimaging can help us evaluate treatments for patients with ASD and other neurodevelopmental disorders.
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Published Articles
Results are displayed in descending order beginning with most recent publications.
Resting State Functional Magnetic Resonance Imaging Elucidates Neurotransmitter Deficiency in Autism Spectrum Disorder
McCarty PJ, Pines AR, Sussman BL, Wyckoff SN, Jensen A, Bunch R, Boerwinkle VL, Frye RE. J Pers Med. 2021 Sep 28;11(10):969. doi: 10.3390/jpm11100969. PMID: 34683111; PMCID: PMC8537605.
Resting State Functional Magnetic Resonance Imaging Elucidates Neurotransmitter Deficiency in Autism Spectrum Disorder
McCarty PJ, Pines AR, Sussman BL, Wyckoff SN, Jensen A, Bunch R, Boerwinkle VL, Frye RE. Resting State Functional Magnetic Resonance Imaging Elucidates Neurotransmitter Deficiency in Autism Spectrum Disorder. J Pers Med. 2021 Sep 28;11(10):969. doi: 10.3390/jpm11100969. PMID: 34683111; PMCID: PMC8537605.
Locked-in Intact Functional Networks in Children with Autism Spectrum Disorder: A Case-Control Study
Pines AR, Sussman B, Wyckoff SN, McCarty PJ, Bunch R, Frye RE, Boerwinkle VL. Locked-in Intact Functional Networks in Children with Autism Spectrum Disorder: A Case-Control Study. J Pers Med. 2021 Aug 28;11(9):854. doi: 10.3390/jpm11090854. PMID: 34575631; PMCID: PMC8465896.
Entorhinal Cortex Thickness across the Human Lifespan
Hasan KM, Mwangi B, Cao B, Keser Z, Tustison NJ, Kochunov P, Frye RE, Savatic M, Soares J. Entorhinal Cortex Thickness across the Human Lifespan. J Neuroimaging. 2016 May;26(3):278-82. doi: 10.1111/jon.12297. Epub 2015 Oct 8. PMID: 26565394; PMCID: PMC4826319.
A lack of statistical pitfalls in the comparison of multivariate causality measures for effective causality
Frye RE. A lack of statistical pitfalls in the comparison of multivariate causality measures for effective causality. Comput Biol Med. 2013 Aug 1;43(7):962-5. doi: 10.1016/j.compbiomed.2013.02.001. Epub 2013 Feb 26. PMID: 23485200.
Tract-based spatial statistics reveal altered relationship between non-verbal reasoning abilities and white matter integrity in autism spectrum disorder
Ellmore TM, Li H, Xue Z, Wong ST, Frye RE. Tract-based spatial statistics reveal altered relationship between non-verbal reasoning abilities and white matter integrity in autism spectrum disorder. J Int Neuropsychol Soc. 2013 Jul;19(6):723-8. doi: 10.1017/S1355617713000325. Epub 2013 Apr 8. PMID: 23561717.
Synchronization between the anterior and posterior cortex determines consciousness level in patients with traumatic brain injury (TBI)
Leon-Carrion J, Leon-Dominguez U, Pollonini L, Wu MH, Frye RE, Dominguez-Morales MR, Zouridakis G. Synchronization between the anterior and posterior cortex determines consciousness level in patients with traumatic brain injury (TBI). Brain Res. 2012 Oct 2;1476:22-30. doi: 10.1016/j.brainres.2012.03.055. Epub 2012 Mar 29. PMID: 22534483.
Network‐based analysis reveals stronger local diffusion‐based connectivity and different correlations with oral language skills in brains of children with high functioning autism spectrum disorders
Li H, Xue Z, Ellmore TM, Frye RE, Wong ST. Network-based analysis reveals stronger local diffusion-based connectivity and different correlations with oral language skills in brains of children with high functioning autism spectrum disorders. Hum Brain Mapp. 2014 Feb;35(2):396-413. doi: 10.1002/hbm.22185. Epub 2012 Sep 24. PMID: 23008187; PMCID: PMC6869619.
Laterality of temporoparietal causal connectivity during the prestimulus period correlates with phonological decoding task performance in dyslexic and typical readers
Frye RE, Liederman J, McGraw Fisher J, Wu MH. Laterality of temporoparietal causal connectivity during the prestimulus period correlates with phonological decoding task performance in dyslexic and typical readers. Cereb Cortex. 2012 Aug;22(8):1923-34. doi: 10.1093/cercor/bhr265. Epub 2011 Oct 6. PMID: 21980019; PMCID: PMC3394369.
Global cerebral and regional multimodal neuroimaging markers of the neurobiology of autism: development and cognition
Hasan KM, Walimuni IS, Frye RE. Global cerebral and regional multimodal neuroimaging markers of the neurobiology of autism: development and cognition. J Child Neurol. 2013 Jul;28(7):874-85. doi: 10.1177/0883073812452917. Epub 2012 Aug 16. PMID: 22899798.
Multichannel least-squares linear regression provides a fast, accurate, unbiased and robust estimation of Granger causality for neurophysiological data
Frye RE, Wu MH. Multichannel least-squares linear regression provides a fast, accurate, unbiased and robust estimation of Granger causality for neurophysiological data. Comput Biol Med. 2011 Dec;41(12):1118-31. doi: 10.1016/j.compbiomed.2011.04.012. PMID: 21640990.
Diffusion tensor quantification of the relations between microstructural and macrostructural indices of white matter and reading
Frye RE, Liederman J, Hasan KM, Lincoln A, Malmberg B, McLean J 3rd, Papanicolaou A. Diffusion tensor quantification of the relations between microstructural and macrostructural indices of white matter and reading. Hum Brain Mapp. 2011 Aug;32(8):1220-35. doi: 10.1002/hbm.21103. Epub 2010 Jul 27. PMID: 20665719; PMCID: PMC6869925.
A comparison of multivariate causality based measures of effective connectivity
Wu MH, Frye RE, Zouridakis G. A comparison of multivariate causality based measures of effective connectivity. Comput Biol Med. 2011 Dec;41(12):1132-41. doi: 10.1016/j.compbiomed.2011.06.007. Epub 2011 Jul 13. PMID: 21742321.
Diffusion tensor‐based regional gray matter tissue segmentation using the international consortium for brain mapping atlases
Hasan KM, Frye RE. Diffusion tensor-based regional gray matter tissue segmentation using the international consortium for brain mapping atlases. Hum Brain Mapp. 2011 Jan;32(1):107-17. doi: 10.1002/hbm.21004. PMID: 20799340; PMCID: PMC6869994.
Greater Pre-Stimulus Effective Connectivity from the Left Inferior Frontal Area to other Areas is Associated with Better Phonological Decoding in Dyslexic Readers
Frye RE, Wu MH, Liederman J, Fisher JM. Greater Pre-Stimulus Effective Connectivity from the Left Inferior Frontal Area to other Areas is Associated with Better Phonological Decoding in Dyslexic Readers. Front Syst Neurosci. 2010 Dec 2;4:156. doi: 10.3389/fnsys.2010.00156. PMID: 21160549; PMCID: PMC3001755.
Diffusion tensor tractography of the human brain cortico-ponto-cerebellar pathways: a quantitative preliminary study
Kamali A, Kramer LA, Frye RE, Butler IJ, Hasan KM. Diffusion tensor tractography of the human brain cortico-ponto-cerebellar pathways: a quantitative preliminary study. J Magn Reson Imaging. 2010 Oct;32(4):809-17. doi: 10.1002/jmri.22330. PMID: 20882611; PMCID: PMC4492525.
Human brain atlas-based volumetry and relaxometry: application to healthy development and natural aging
Hasan KM, Walimuni IS, Kramer LA, Frye RE. Human brain atlas-based volumetry and relaxometry: application to healthy development and natural aging. Magn Reson Med. 2010 Nov;64(5):1382-9. doi: 10.1002/mrm.22515. Epub 2010 Aug 25. PMID: 20740662.
Preterm birth and maternal responsiveness during childhood are associated with brain morphology in adolescence
Frye RE, Malmberg B, Swank P, Smith K, Landry S. Preterm birth and maternal responsiveness during childhood are associated with brain morphology in adolescence. J Int Neuropsychol Soc. 2010 Sep;16(5):784-94. doi: 10.1017/S1355617710000585. Epub 2010 Jul 8. PMID: 20609271.
Superior longitudinal fasciculus and cognitive dysfunction in adolescents born preterm and at term
Frye RE, Hasan K, Malmberg B, Desouza L, Swank P, Smith K, Landry S. Superior longitudinal fasciculus and cognitive dysfunction in adolescents born preterm and at term. Dev Med Child Neurol. 2010 Aug;52(8):760-6. doi: 10.1111/j.1469-8749.2010.03633.x. Epub 2010 Feb 24. PMID: 20187879; PMCID: PMC2910222.
Increased left prefrontal activation during an auditory language task in adolescents born preterm at high risk
Frye RE, Malmberg B, McLean J 3rd, Swank P, Smith K, Papanicolaou A, Landry S. Increased left prefrontal activation during an auditory language task in adolescents born preterm at high risk. Brain Res. 2010 Jun 8;1336:89-97. doi: 10.1016/j.brainres.2010.03.093. Epub 2010 Apr 8. PMID: 20381475; PMCID: PMC2881563.
Information communication networks in severe traumatic brain injury
Pollonini L, Pophale S, Situ N, Wu MH, Frye RE, Leon-Carrion J, Zouridakis G. Information communication networks in severe traumatic brain injury. Brain Topogr. 2010 Jun;23(2):221-6. doi: 10.1007/s10548-010-0139-9. Epub 2010 Mar 12. PMID: 20224956.
Surface Area Accounts for the Relation of Gray Matter Volume to Reading-Related Skills and History of Dyslexia
Frye RE, Liederman J, Malmberg B, McLean J, Strickland D, Beauchamp MS. Surface area accounts for the relation of gray matter volume to reading-related skills and history of dyslexia. Cereb Cortex. 2010 Nov;20(11):2625-35. doi: 10.1093/cercor/bhq010. Epub 2010 Feb 12. PMID: 20154011; PMCID: PMC2981021.
Increased prefrontal activation in adolescents born prematurely at high risk during a reading task
Frye RE, Malmberg B, Desouza L, Swank P, Smith K, Landry S. Increased prefrontal activation in adolescents born prematurely at high risk during a reading task. Brain Res. 2009 Dec 15;1303:111-9. doi: 10.1016/j.brainres.2009.09.091. Epub 2009 Sep 29. PMID: 19796631; PMCID: PMC2783693.
Reversible posterior leukoencephalopathy syndrome in sickle-cell anemia
Frye RE. Reversible posterior leukoencephalopathy syndrome in sickle-cell anemia. Pediatr Neurol. 2009 Apr;40(4):298-301. doi: 10.1016/j.pediatrneurol.2008.10.024. PMID: 19302944; PMCID: PMC2903963.
Functional Neuroimaging of Language Using Magnetoencephalography
Frye RE, Rezaie R, Papanicolaou AC. Functional Neuroimaging of Language Using Magnetoencephalography. Phys Life Rev. 2009 Mar 1;6(1):1-10. doi: 10.1016/j.plrev.2008.08.001. PMID: 20160985; PMCID: PMC2754842.
