Interview with Dr. Richard Frye, a pediatric neurologist and internationally recognized autism researcher, about Folinic Acid, Leucovorin and Autism. Dr. Frye focuses on the biological aspects of autism, including folate pathways, the immune system, metabolism, and mitochondrial function.
Posted by: McKenzie Beard, New York Post
Posted on: March 7, 2025, 12:09 p.m. ET
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Frye RE, Slattery J, Delhey L, Furgerson B, Strickland T, Tippett M, Sailey A, Wynne R, Rose S, Melnyk S, Jill James S, Sequeira JM, Quadros EV. Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial. Mol Psychiatry. 2018 Feb;23(2):247-256. doi: 10.1038/mp.2016.168. Epub 2016 Oct 18. PMID: 27752075; PMCID: PMC5794882.
Frye RE, Slattery J, Delhey L, Furgerson B, Strickland T, Tippett M, Sailey A, Wynne R, Rose S, Melnyk S, Jill James S, Sequeira JM, Quadros EV. Mol Psychiatry. 2018; 23(2):247-256.
Frye RE, Melnyk S, Fuchs G, Reid T, Jernigan S, Pavliv O, Hubanks A, Gaylor DW, Walters L, James SJ. Effectiveness of methylcobalamin and folinic Acid treatment on adaptive behavior in children with autistic disorder is related to glutathione redox status. Autism Res Treat. 2013;2013:609705. doi: 10.1155/2013/609705. Epub 2013 Oct 12. PMID: 24224089; PMCID: PMC3810468.
Frye RE, Sequeira JM, Quadros EV, James SJ, Rossignol DA. Mol Psychiatry. 2013; 18(3):369-81.
