Children with autism are showing ‘dramatic improvement’ with this cheap drug — and doctor behind its research says it may one day prevent the disorder
Posted by: McKenzie Beard, New York Post
Posted on: March 19, 2025, 6:00 a.m. ET
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All about Leucovorin & Benefits for the Autistic Phenotype
Title: Dr. Richard Frye, MD, PhD: All about Leucovorin & Benefits for the Autistic Phenotype
Date: March 31, 2025
Host: From the Spectrum Podcast
Interview: Dr. Richard Frye, MD PhD
The Lisa Wexler Show – Groundbreaking Research In Autism Outcomes
Posted by: The Lisa Wexler Show
Posted on: March 28, 2025
Open Radio Show
Taking this supplement while pregnant can make your baby smarter: study
Posted by: McKenzie Beard, New York Post
Posted on: March 7, 2025, 12:09 p.m. ET
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TACA: Leucovorin and Autism
Posted by: The Autism Community in Action (TACA) Now Blog
Posted on: March 3, 2025
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Autism Parenting Secrets: Evidence-Based Treatments
Posted by: Autism Parenting Secrets Podcast
Posted on: February 27, 2025
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Binding Folate Receptor Alpha Autoantibody Is a Biomarker for Leucovorin Treatment Response in Autism Spectrum Disorder
Frye RE, McCarty PJ, Werner BA, Scheck AC, Collins HL, Adelman SJ, Rossignol DA, Quadros EV. J Pers Med. 1 Jan 2024.
Is a Folate Deficiency Worsening Your Child’s Autism?
Posted by: Potomac Psychiatry
Posted on: April 13, 2023
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Levoleucovorin Treatment for Autism
Title: Levoleucovorin Treatment for Autism
Date: December 2022
Location: Synchrony 2022 – The BRAIN Foundation
Presented by: Dr. Richard Frye, MD PhD
The Soluble Folate Receptor in Autism Spectrum Disorder: Relation to Autism Severity and Leucovorin Treatment.
Frye RE, Lane A, Worner A, Werner BA, McCarty PJ, Scheck AC, Collins HL, Adelman SJ, Quadros EV, Rossignol DA. J Pers Med. 2022 Dec 8;12(12):2033. doi: 10.3390/jpm12122033. PMID: 36556254; PMCID: PMC9786140.
Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid) Treatment in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis
Rossignol DA, Frye RE. J Pers Med. 2021 Nov 3;11(11):1141. doi: 10.3390/jpm11111141. Erratum in: J Pers Med. 2022 Apr 29;12(5): PMID: 34834493; PMCID: PMC8622150.
Treatment of Folate Metabolism Abnormalities in Autism Spectrum Disorder
Frye RE, Rossignol DA, Scahill L, McDougle CJ, Huberman H, Quadros EV. Semin Pediatr Neurol. 2020 Oct;35:100835. doi: 10.1016/j.spen.2020.100835. Epub 2020 Jun 25. PMID: 32892962; PMCID: PMC7477301.
Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial
Frye RE, Slattery J, Delhey L, Furgerson B, Strickland T, Tippett M, Sailey A, Wynne R, Rose S, Melnyk S, Jill James S, Sequeira JM, Quadros EV. Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial. Mol Psychiatry. 2018 Feb;23(2):247-256. doi: 10.1038/mp.2016.168. Epub 2016 Oct 18. PMID: 27752075; PMCID: PMC5794882.