Research Articles and Other Resources
PROFESSIONAL DISCLAIMER
The Site cannot and does not contain medical/health advice. The medical/health information is provided for general informational and educational purposes only and is not a substitute for professional advice. Accordingly, before taking any actions based upon such information, we encourage you to consult with the appropriate professionals. We do not provide any kind of medical/health advice. THE USE OR RELIANCE OF ANY INFORMATION CONTAINED ON THE SITE OR OUR MOBILE APPLICATION IS SOLELY AT YOUR OWN RISK.
The Effect of Mitochondrial Supplements on Mitochondrial Activity in Children with Autism Spectrum Disorder.
Delhey, L.M., Nur Kilinc, E., Yin, L., Slattery, J.C., Tippett, M.L., Rose, S., Bennuri, S.C., Kahler, S.G., Damle, S., Legido, A., Goldenthal, M.J., Frye, R.E. J Clin Med. 2017; 6(2). pii: E18.
Thyroid dysfunction in children withautism spectrum disorder is associated with folate receptor α autoimmune disorder.
Frye RE, Wynne R, Rose S, Slattery J, Delhey L, Tippett M, Kahler SG, Bennuri SC, Melnyk S, Sequeira JM, Quadros EV. J Neuroendocrinol. 2017; 29(3).
Mitochondrial and redox abnormalities in autism lymphoblastoid cells: a sibling control study
Rose S, Bennuri SC, Wynne R, Melnyk S, James SJ, Frye RE. FASEB J. 2017; 31(3):904-909.
Modulation of mitochondrial function by the microbiome metabolite propionic acid in autism and control cell lines
Frye RE, Rose S, Chacko J, Wynne R, Bennuri SC, Slattery JC, Tippett M, Delhey L, Melnyk S, Kahler SG, MacFabe DF. Transl Psychiatry. 2016 Oct 25;6(10):e927. doi: 10.1038/tp.2016.189. PMID: 27779624; PMCID: PMC5290345.
The Significance of the Enteric Microbiome on the Development of Childhood Disease: A Review of Prebiotic and Probiotic Therapies in Disorders of Childhood.
Rose, S., Bennuri, S..C, Davis, J.E., Wynne, R., Slattery, J.C., Tippett, M., Delhey, L., Melnyk, S., Kahler, S.G., MacFabe, D.F., Frye, R.E.. Transl Psychiatry. 2018; 8(1):42.
Primary Mitochondrial Disease and Secondary Mitochondrial Dysfunction: Importance of Distinction for Diagnosis and Treatment
Niyazov DM, Kahler SG, Frye RE. Primary Mitochondrial Disease and Secondary Mitochondrial Dysfunction: Importance of Distinction for Diagnosis and Treatment. Mol Syndromol. 2016 Jul;7(3):122-37. doi: 10.1159/000446586. Epub 2016 Jun 3. PMID: 27587988; PMCID: PMC4988248.
Identification and Treatment of Pathophysiological Comorbidities of Autism Spectrum Disorder to Achieve Optimal Outcomes
Frye RE, Rossignol DA. Identification and Treatment of Pathophysiological Comorbidities of Autism Spectrum Disorder to Achieve Optimal Outcomes. Clin Med Insights Pediatr. 2016 Jun 15;10:43-56. doi: 10.4137/CMPed.S38337. PMID: 27330338; PMCID: PMC4910649.
Neuropathological Mechanisms of Seizures in Autism Spectrum Disorder
Frye RE, Casanova MF, Fatemi SH, Folsom TD, Reutiman TJ, Brown GL, Edelson SM, Slattery JC, Adams JB. Front Neurosci. 2016 May 10;10:192. doi: 10.3389/fnins.2016.00192. PMID: 27242398; PMCID: PMC4861974.
Mitochondrial Dysfunction may explain symptom variation in Phelan-McDermid Syndrome.
Frye, R.E., Cox, D., Slattery, J., Tippett, M., Kahler, S., Granpeesheh, D., Damle, S., Legido, A., Goldenthal, M.J. Sci Rep. 2016 Jan 29;6:19544.
Blocking and Binding Folate Receptor Alpha Autoantibodies Identify Novel Autism Spectrum Disorder Subgroups
Frye RE, Delhey L, Slattery J, Tippett M, Wynne R, Rose S, Kahler SG, Bennuri SC, Melnyk S, Sequeira JM, Quadros E. Front Neurosci. 2016; 10:80.
Environmental Toxicants and Autism Spectrum Disorder
Rossignol, D.A., Frye, R.E. Psychiatric Times. 2016; 33(9)
Enteric Ecosystem Disruption in Autism Spectrum Disorder: Can the Microbiota and Macrobiota be Restored?
Slattery J, MacFabe DF, Kahler SG, Frye RE. Curr Pharm Des. 2016;22(40):6107-6121. doi: 10.2174/1381612822666160905123953. PMID: 27592717.
Treatment for Sleep Problems in Children with Autism and Caregiver Spillover Effects
Tilford JM, Payakachat N, Kuhlthau KA, Pyne JM, Kovacs E, Bellando J, Williams DK, Brouwer WB, Frye RE. Treatment for Sleep Problems in Children with Autism and Caregiver Spillover Effects. J Autism Dev Disord. 2015 Nov;45(11):3613-23. doi: 10.1007/s10803-015-2507-5. PMID: 26126749; PMCID: PMC4609586.
Entorhinal Cortex Thickness across the Human Lifespan
Hasan KM, Mwangi B, Cao B, Keser Z, Tustison NJ, Kochunov P, Frye RE, Savatic M, Soares J. Entorhinal Cortex Thickness across the Human Lifespan. J Neuroimaging. 2016 May;26(3):278-82. doi: 10.1111/jon.12297. Epub 2015 Oct 8. PMID: 26565394; PMCID: PMC4826319.
Approaches to studying and manipulating the enteric microbiome to improve autism symptoms
Frye RE, Slattery J, MacFabe DF, Allen-Vercoe E, Parker W, Rodakis J, Adams JB, Krajmalnik-Brown R, Bolte E, Kahler S, Jennings J, James J, Cerniglia CE, Midtvedt T. Microb Ecol Health Dis. 2015 May 7;26:26878. doi: 10.3402/mehd.v26.26878. PMID: 25956237; PMCID: PMC4425814.
Sudden Onset Complex Tic Associated with Streptococcal Infection in a Neonate: The First Case of Neonatal PANDAS
Frye, R.E. N A J Med Sci. 2015;8(2):92-95
Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome.
Frye, R.E., Rose, S., Slattery, J., MacFabe, D.F. Microb Ecol Health Dis. 2015; 26:27458.
Metabolic and mitochondrial disorders associated with epilepsy in children with autism spectrum disorder.
Frye RE. Epilepsy Behav. 2015; 47:147-57.
Supplement 1, 2015: The Microbiome in Autism Spectrum Disorder
Richard E. Frye & John Slattery. Originally published in Microbial Ecology in Health and Disease, Volume: 26, Number: 1 (01 Dec 2015)
Treatments for biomedical abnormalities associated with autism spectrum disorder
Frye RE, Rossignol DA. Treatments for biomedical abnormalities associated with autism spectrum disorder. Front Pediatr. 2014 Jun 27;2:66. doi: 10.3389/fped.2014.00066. PMID: 25019065; PMCID: PMC4073259.
Clinical potential, safety, and tolerability of arbaclofen in the treatment of autism spectrum disorder
Frye RE. Clinical potential, safety, and tolerability of arbaclofen in the treatment of autism spectrum disorder. Drug Healthc Patient Saf. 2014 May 10;6:69-76. doi: 10.2147/DHPS.S39595. PMID: 24872724; PMCID: PMC4025936.
Oxidative stress induces mitochondrial dysfunction in a subset of autistic lymphoblastoid cell lines.
Rose, S., Frye, R.E., Slattery, J., Wynne, R., Tippett, M., Melnyk, S., James, S.J. Transl Psychiatry. 2014; 4:e377.
Oxidative stress induces mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines in a well-matched case control cohort.
Rose, S., Frye, R.E., Slattery, J., Wynne, R., Tippett, M., Pavliv, O., Melnyk, S., James, S.J. PLoS One. 2014; 9(1):e85436.
Environmental toxicants and autism spectrum disorders: a systematic review.
Rossignol, D.A., Genuis, S.J., Frye, R.E. Transl Psychiatry. 2014; 4:e360.
Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism.
Rossignol, D.A., Frye, R.E. Front Physiol. 2014; 22;5:150.