Research Articles and Other Resources
PROFESSIONAL DISCLAIMER
The Site cannot and does not contain medical/health advice. The medical/health information is provided for general informational and educational purposes only and is not a substitute for professional advice. Accordingly, before taking any actions based upon such information, we encourage you to consult with the appropriate professionals. We do not provide any kind of medical/health advice. THE USE OR RELIANCE OF ANY INFORMATION CONTAINED ON THE SITE OR OUR MOBILE APPLICATION IS SOLELY AT YOUR OWN RISK.
Effectiveness of methylcobalamin and folinic Acid treatment on adaptive behavior in children with autistic disorder is related to glutathione redox status
Frye RE, Melnyk S, Fuchs G, Reid T, Jernigan S, Pavliv O, Hubanks A, Gaylor DW, Walters L, James SJ. Effectiveness of methylcobalamin and folinic Acid treatment on adaptive behavior in children with autistic disorder is related to glutathione redox status. Autism Res Treat. 2013;2013:609705. doi: 10.1155/2013/609705. Epub 2013 Oct 12. PMID: 24224089; PMCID: PMC3810468.
A review of traditional and novel treatments for seizures in autism spectrum disorder: findings from a systematic review and expert panel
Frye RE, Rossignol D, Casanova MF, Brown GL, Martin V, Edelson S, Coben R, Lewine J, Slattery JC, Lau C, Hardy P, Fatemi SH, Folsom TD, Macfabe D, Adams JB. Front Public Health. 2013 Sep 13;1:31. doi: 10.3389/fpubh.2013.00031. PMID: 24350200; PMCID: PMC3859980.
A lack of statistical pitfalls in the comparison of multivariate causality measures for effective causality
Frye RE. A lack of statistical pitfalls in the comparison of multivariate causality measures for effective causality. Comput Biol Med. 2013 Aug 1;43(7):962-5. doi: 10.1016/j.compbiomed.2013.02.001. Epub 2013 Feb 26. PMID: 23485200.
Tract-based spatial statistics reveal altered relationship between non-verbal reasoning abilities and white matter integrity in autism spectrum disorder
Ellmore TM, Li H, Xue Z, Wong ST, Frye RE. Tract-based spatial statistics reveal altered relationship between non-verbal reasoning abilities and white matter integrity in autism spectrum disorder. J Int Neuropsychol Soc. 2013 Jul;19(6):723-8. doi: 10.1017/S1355617713000325. Epub 2013 Apr 8. PMID: 23561717.
Metabolic effects of sapropterin treatment in autism spectrum disorder: a preliminary study
Frye RE, DeLatorre R, Taylor HB, Slattery J, Melnyk S, Chowdhury N, James SJ. Metabolic effects of sapropterin treatment in autism spectrum disorder: a preliminary study. Transl Psychiatry. 2013 Mar 5;3(3):e237. doi: 10.1038/tp.2013.14. PMID: 23462988; PMCID: PMC3625913.
Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder.
Frye, R.E., Melnyk, S., Macfabe, D.F. Transl Psychiatry. 2013; 3:e220.
Redox Metabolism Abnormalities in Autistic Children Associated with Mitochondrial Disease
Frye, R.E., DeLaTorre, R. Taylor, H. Slattery, J., Melnyk, S. James, S.J.Translational Psychiatry, 2013 3:e273. DOI: 10.1038/tp.2013.51. PMID: 23778583
Synchronization between the anterior and posterior cortex determines consciousness level in patients with traumatic brain injury (TBI)
Leon-Carrion J, Leon-Dominguez U, Pollonini L, Wu MH, Frye RE, Dominguez-Morales MR, Zouridakis G. Synchronization between the anterior and posterior cortex determines consciousness level in patients with traumatic brain injury (TBI). Brain Res. 2012 Oct 2;1476:22-30. doi: 10.1016/j.brainres.2012.03.055. Epub 2012 Mar 29. PMID: 22534483.
Network‐based analysis reveals stronger local diffusion‐based connectivity and different correlations with oral language skills in brains of children with high functioning autism spectrum disorders
Li H, Xue Z, Ellmore TM, Frye RE, Wong ST. Network-based analysis reveals stronger local diffusion-based connectivity and different correlations with oral language skills in brains of children with high functioning autism spectrum disorders. Hum Brain Mapp. 2014 Feb;35(2):396-413. doi: 10.1002/hbm.22185. Epub 2012 Sep 24. PMID: 23008187; PMCID: PMC6869619.
Laterality of temporoparietal causal connectivity during the prestimulus period correlates with phonological decoding task performance in dyslexic and typical readers
Frye RE, Liederman J, McGraw Fisher J, Wu MH. Laterality of temporoparietal causal connectivity during the prestimulus period correlates with phonological decoding task performance in dyslexic and typical readers. Cereb Cortex. 2012 Aug;22(8):1923-34. doi: 10.1093/cercor/bhr265. Epub 2011 Oct 6. PMID: 21980019; PMCID: PMC3394369.
Global cerebral and regional multimodal neuroimaging markers of the neurobiology of autism: development and cognition
Hasan KM, Walimuni IS, Frye RE. Global cerebral and regional multimodal neuroimaging markers of the neurobiology of autism: development and cognition. J Child Neurol. 2013 Jul;28(7):874-85. doi: 10.1177/0883073812452917. Epub 2012 Aug 16. PMID: 22899798.
A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures.
Rossignol, D.A., Frye, R.E. Mol Psychiatry. 2012; 17(4):389-401.
Substantial problems with measuring brain mitochondrial dysfunction in autism spectrum disorder using magnetic resonance spectroscopy.
Rossignol, D.A., Frye, R.E. J Autism Dev Disord. 2012; 42(4):640-2.
Mitochondrial disease in 22q13 duplication syndrome.
Frye RE. J Child Neurol. 2012; 27(7):942-9.
Mitochondrial Dysfunction in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis.
Rossignol, D., Frye, R.E. Molecular Psychiatry, 2012; 17(3):290-314. DOI: 10.1038/mp.2010.136. PMID: 21263444
Cerebral folate receptor autoantibodies in autism spectrum disorder.
Frye RE, Sequeira JM, Quadros EV, James SJ, Rossignol DA. Mol Psychiatry. 2013; 18(3):369-81.
Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain.
Rose S, Melnyk S, Pavliv O, Bai S, Nick TG, Frye RE, James SJ. Transl Psychiatry. 2012 Jul 10;2:e134.
Cerebral folate receptor autoantibodies in autism spectrum disorder
Frye RE, Sequeira JM, Quadros EV, James SJ, Rossignol DA. Cerebral folate receptor autoantibodies in autism spectrum disorder. Mol Psychiatry. 2013 Mar;18(3):369-81. doi: 10.1038/mp.2011.175. Epub 2012 Jan 10. PMID: 22230883; PMCID: PMC3578948.
Multichannel least-squares linear regression provides a fast, accurate, unbiased and robust estimation of Granger causality for neurophysiological data
Frye RE, Wu MH. Multichannel least-squares linear regression provides a fast, accurate, unbiased and robust estimation of Granger causality for neurophysiological data. Comput Biol Med. 2011 Dec;41(12):1118-31. doi: 10.1016/j.compbiomed.2011.04.012. PMID: 21640990.
Melatonin in autism spectrum disorders: a systematic review and meta-analysis
Rossignol DA, Frye RE. Melatonin in autism spectrum disorders: a systematic review and meta-analysis. Dev Med Child Neurol. 2011 Sep;53(9):783-792. doi: 10.1111/j.1469-8749.2011.03980.x. Epub 2011 Apr 19. PMID: 21518346.
Diffusion tensor quantification of the relations between microstructural and macrostructural indices of white matter and reading
Frye RE, Liederman J, Hasan KM, Lincoln A, Malmberg B, McLean J 3rd, Papanicolaou A. Diffusion tensor quantification of the relations between microstructural and macrostructural indices of white matter and reading. Hum Brain Mapp. 2011 Aug;32(8):1220-35. doi: 10.1002/hbm.21103. Epub 2010 Jul 27. PMID: 20665719; PMCID: PMC6869925.
A comparison of multivariate causality based measures of effective connectivity
Wu MH, Frye RE, Zouridakis G. A comparison of multivariate causality based measures of effective connectivity. Comput Biol Med. 2011 Dec;41(12):1132-41. doi: 10.1016/j.compbiomed.2011.06.007. Epub 2011 Jul 13. PMID: 21742321.
Traditional and non-traditional treatments for autism spectrum disorder with seizures: an on-line survey
Frye RE, Sreenivasula S, Adams JB. BMC Pediatr. 2011 May 18;11:37. doi: 10.1186/1471-2431-11-37. PMID: 21592359; PMCID: PMC3123184.
A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures
Rossignol DA, Frye RE. A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures. Mol Psychiatry. 2012 Apr;17(4):389-401. doi: 10.1038/mp.2011.165. Epub 2011 Dec 6. PMID: 22143005; PMCID: PMC3317062.
Mitochondrial dysfunction can connect the diverse medical symptoms associated with autism spectrum disorders.
Frye, R.E., Rossignol, D.A. Pediatr Res. 2011; 69(5 Pt 2):41R-7R.